Located on the south coast of the island, it borders the district of Manatuto to the east, Aileu to the north, Ainaro to the west and the Timor Sea to the south. It has a population of 48,628 inhabitants (Census 2010) and an area of 1,325 km2. The capital of the district is Same.
Manufahi is mountainous in the north with extensive coastal plains to the south that are suitable for wet rice cultivation. It has perennial rivers.
Manufahi is a rural agricultural district where small farmers practice traditional agriculture, generally growing non-irrigated rice, corn, cassava, beans and tubers. Coffee is grown in the north, and coconuts in the south.
Same as Suai and Viquque, Betano Refinery will be built to support the implementation of the multi-year Tasi-Mane project.